期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 9, 期 22, 页码 4567-4576出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1tb00724f
关键词
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资金
- National Natural Science Foundation of China [21875168, 21674083]
- National Key RAMP
- D program of China [2018YFB1105502]
The injectable photothermally active antibacterial composite hydrogel based on HPCH/TA/Fe demonstrated effective prevention of bacterial infection, accelerated wound closure, and good biocompatibility. Combining low-level laser therapy with the hydrogel resulted in accelerated wound closure and promotion of skin tissue repair.
Prevention of bacterial infection, acceleration of wound closure and promotion of skin regeneration are crucial in the wound healing process. In this work, the photothermal activity of an injectable thermosensitive composite hydrogel based on hydroxypropyl chitin (HPCH), tannic acid (TA) and ferric ions (Fe3+) was studied. It was found that the photothermal efficiency was enhanced when the molar ratio of Fe3+/TA increased up to 20. The composite hydrogel possessed good cytocompatibility and hemocompatibility with a low dosage of the antibacterial agent TA. In vitro and in vivo antibacterial tests showed that the HPCH/TA/Fe hydrogel possessed an effective and rapid bactericidal effect with 10 minutes of near-infrared laser irradiation. Furthermore, the combination of a low-level laser therapy with the hydrogel is conducive to the acceleration of wound closure and promotion of skin tissue repair. Thus, the injectable photothermally active antibacterial composite hydrogel has great potential for the infected skin wound regeneration in clinical applications.
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