Recent developments in decarboxylative C(aryl)-X bond formation from (hetero)aryl carboxylic acids

Decarboxylative coupling reactions using readily available (hetero)aryl carboxylic acids are a highly efficient approach for the formation of new C-C and C-X bonds. These decarboxylative coupling reactions eliminate CO2 as a by-product, resulting in a greener and environmentally more benign approach than conventional coupling reactions. In this review, we summarize the recent developments in ipso-decarboxylative C-X (X = O/N/halo/S/Se/P/CN) bond formations using (hetero)aryl carboxylic acids. Furthermore, we highlight the current limitations and future research opportunities of aryl-decarboxylative coupling reactions.

Automated summary

Decarboxylative coupling reactions using readily available (hetero)aryl carboxylic acids are an efficient approach for forming new C-C and C-X bonds, with the advantage of eliminating CO2 as a by-product and being more environmentally friendly. This review summarizes recent developments in ipso-decarboxylative C-X bond formations using (hetero)aryl carboxylic acids, and highlights current limitations and future research opportunities in aryl-decarboxylative coupling reactions.