期刊
HELIYON
卷 7, 期 4, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.heliyon.2021.e06845
关键词
Achilles tendon; Tendon injury; Astrocyte reactivity; Gait; Mechanical sensitivity
资金
- Fundacao Amazonia de Amparo a Estudos e Pesquisas (FAPESPA)
- Pro-Reitoria de Pesquisa e Pos-Graduacao da Universidade Federal do Para (PROPESP/UFPA)
This study found that astrocyte reactivity in the spinal cord occurs during the acute phase of Achilles tendon repair, leading to impairment of mechanical sensitivity and gait, while only gait impairment remains in the chronic phase.
Astrocyte reactivity in the spinal cord may occur after peripheral neural damage. However, there is no data to report such reactivity after Achilles tendon injury. We investigate whether changes occur in the spinal cord, mechanical sensitivity and gait in two phases of repair after Achilles tendon injury. Wistar rats were divided into groups: control (CTRL, without rupture), 2 days post-injury (RUP2) and 21 days post-injury (RUP21). Functional and mechanical sensitivity tests were performed at 2 and 21 days post-injury (dpi). The spinal cords were processed, cryosectioned and activated astrocytes were immunostained by GFAP at 21 dpi. Astrocyte reactivity was observed in the L5 segment of the spinal cord with predominance in the white matter regions and decrease in the mechanical threshold of the ipsilateral paw only in RUP2. However, there was gait impairment in both RUP2 and RUP21. We conclude that during the acute phase of Achilles tendon repairment, there was astrocyte reactivity in the spinal cord and impairment of mechanical sensitivity and gait, whereas in the chronic phase only gait remains compromised.
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