相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Wortmannolol Induces Breast Cancer Cell Death In Vitro and In Vivo by Targeting Phosphoinositide 3-Kinase α
Yan He et al.
CHEMISTRYSELECT (2020)
Asymmetric total synthesis of nodulisporiviridin E
Yang Ji et al.
ORGANIC CHEMISTRY FRONTIERS (2020)
Wortmannin and Wortmannine Analogues from an Undescribed Niesslia sp.
Nicole M. Dischler et al.
JOURNAL OF NATURAL PRODUCTS (2019)
Total Synthesis of Viridin and Viridiol
Yang Ji et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Natural Product Total Synthesis: As Exciting as Ever and Here To Stay
Phil S. Baran
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
Gao-Qian Wang et al.
NATURE COMMUNICATIONS (2018)
Radical Retrosynthesis
Joel M. Smith et al.
ACCOUNTS OF CHEMICAL RESEARCH (2018)
The High Chemofidelity of Metal-Catalyzed Hydrogen Atom Transfer
Samantha A. Green et al.
ACCOUNTS OF CHEMICAL RESEARCH (2018)
Enantioselective Total Synthesis of (+)-Wortmannin
Yinliang Guo et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Enantioselective Chemical Syntheses of the Furanosteroids (-)-Viridin and (-)-Viridiol
Matthew Del Bel et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Fe-Catalyzed C-C Bond Construction from Olefins via Radicals
Julian C. Lo et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
NF-kappa B signaling in inflammation
Ting Liu et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)
Two new compounds, deacetylisowortmins A and B, isolated from an endophytic Fungus, Talaromyces wortmannii LGT-4
Guang-Chao Fu et al.
NATURAL PRODUCT RESEARCH (2016)
A new furanosteroid from Talaromyces sp lgt-4, a fungal endophyte isolated from Tripterygium wilfordii
Kang-Kang Zhi et al.
NATURAL PRODUCT RESEARCH (2016)
Co-Catalyzed Hydroarylation of Unactivated Olefins
Hiroki Shigehisa et al.
ORGANIC LETTERS (2016)
Synthesis of the Privileged 8-Arylmenthol Class by Radical Arylation of Isopulegol
Steven W. M. Crossley et al.
ORGANIC LETTERS (2016)
A unified and common intermediate strategy for the asymmetric total synthesis of 3-deoxy-neo-inositol and conduritol E
Amarendra Panda et al.
TETRAHEDRON LETTERS (2016)
Wortmannines A-C, three novel wortmannin derivatives with an unusual five-membered B ring from the endophytic fungus Talaromyces wortmannii LGT-4
Guang-Chao Fu et al.
TETRAHEDRON LETTERS (2016)
Phosphatidylinositol-3,4,5-Triphosphate and Cellular Signaling: Implications for Obesity and Diabetes
Prasenjit Manna et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)
Nodulisporiviridins A-H, Bioactive Viridins from Nodulisporium sp.
Qin Zhao et al.
JOURNAL OF NATURAL PRODUCTS (2015)
Hydromethylation of Unactivated Olefins
Hai T. Dao et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
Practical olefin hydroamination with nitroarenes
Jinghan Gui et al.
SCIENCE (2015)
Secovironolide, a novel furanosteroid scaffold with a five-membered B ring from the endophytic fungus Talaromyces wortmannii LGT-4
Hai-E. Ding et al.
TETRAHEDRON LETTERS (2015)
Phthalides and Phthalans: Synthetic Methodologies and Their Applications in the Total Synthesis
Raju Karmakar et al.
CHEMICAL REVIEWS (2014)
Simple, Chemoselective, Catalytic Olefin Isomerization
Steven W. M. Crossley et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Enantioselective Total Synthesis of (-)-Maoecrystal V
Changwu Zheng et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol
Kotaro Iwasaki et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Functionalized olefin cross-coupling to construct carbon-carbon bonds
Julian C. Lo et al.
NATURE (2014)
Improved synthesis of 17 beta-hydroxy-16 alpha-iodo-wortmannin, 17 beta-hydroxy-16 alpha-iodoPX866, and the [I-131] analogue as useful PET tracers for PI3-kinase
Duoli Sun et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Antibiotically active metabolites from Talaromyces wortmannii, an endophyte of Aloe vera
Robert Bara et al.
JOURNAL OF ANTIBIOTICS (2013)
Viridin-like steroids from Hymenoscyphus pseudoalbidus
Pierre F. Andersson et al.
PHYTOCHEMISTRY (2013)
Synthetic Studies on Furanosteroids: Construction of the Viridin Core Structure via Diels-Alder/retro-Diels-Alder and Vinylogous Mukaiyama Aldol-Type Reaction
Evans O. Onyango et al.
JOURNAL OF ORGANIC CHEMISTRY (2012)
Furanosteroid studies. Improved synthesis of the A,B,C,E-ring core of viridin
Kristen C. Mascall et al.
TETRAHEDRON LETTERS (2012)
The asymmetric Heck and related reactions
Dennis Mc Cartney et al.
CHEMICAL SOCIETY REVIEWS (2011)
Antifungal and cytotoxic activities of the secondary metabolites from endophytic fungus Massrison sp.
Zhen-Liang Sun et al.
PHYTOMEDICINE (2011)
The Chemical Constituents of Endophytic Fungus Trichoderma sp MFF-1
Guo-Hong Li et al.
CHEMISTRY & BIODIVERSITY (2010)
Hybrid Inhibitors of Phosphatidylinositol 3-Kinase (PI3K) and the Mammalian Target of Rapamycin (mTOR): Design, Synthesis, and Superior Antitumor Activity of Novel Wortmannin-Rapamycin Conjugates
Semiramis Ayral-Kaloustian et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
The Enantiocontrolled Synthesis of a Highly Functionalized Cyclohexenone Related to the A-Ring of the Furanosteroid Viridin
Alison D. Findlay et al.
AUSTRALIAN JOURNAL OF CHEMISTRY (2009)
A stabilized demethoxyviridin derivative inhibits PI3 kinase
Hushan Yuan et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Pentacyclic Furanosteroids: The Synthesis of Potential Kinase Inhibitors Related to Viridin and Wortmannolone
Yunhui Lang et al.
JOURNAL OF ORGANIC CHEMISTRY (2009)
Asymmetric Synthesis of Diamine Derivatives via Sequential Palladium and Rhodium Catalysis
Barry M. Trost et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
A Hypervalent Iodine-Induced Double Annulation Enables a Concise Synthesis of the Pentacyclic Core Structure of the Cortistatins
Jessica L. Frie et al.
ORGANIC LETTERS (2009)
Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: Potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy
Arie Zask et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
A concise synthesis of the pentacyclic framework of cortistatins
Shuji Yamashita et al.
ORGANIC LETTERS (2008)
The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures
Amy L. Howes et al.
MOLECULAR CANCER THERAPEUTICS (2007)
Chemoenzymatic approaches to the montanine alkaloids: A total synthesis of (+)-brunsvigine
Martin G. Banwell et al.
ORGANIC LETTERS (2007)
Furanosteroid studies. Stereoselective synthesis of the A,B,E-ring core of wortmannin
E. Hampton Sessions et al.
ORGANIC LETTERS (2007)
Intramolecular nitrile oxide-alkene cycloaddition of sugar derivatives with unmasked hydroxyl group(s)
Tony K. M. Shing et al.
ORGANIC LETTERS (2007)
Covalent reactions of Wortmannin under physiological conditions
Hushan Yuan et al.
CHEMISTRY & BIOLOGY (2007)
9-epi-viridiol, a novel cytotoxic furanosteroid from soil fungus Trichoderma virens
Preecha Phuwapraisirisan et al.
NATURAL PRODUCT RESEARCH (2006)
Studies on the synthesis of furanosteroids. I. viridin models
E. Hampton Sessions et al.
ORGANIC LETTERS (2006)
Hydroxy-1-aminoindans and derivatives: Preparation, stability, and reactivity
Yaacov Herzig et al.
JOURNAL OF ORGANIC CHEMISTRY (2006)
Experimental and theoretical studies on stereo- and regioselectivity in intramolecular nitrone-alkene cycloaddition of Hept-6-enoses derived from carbohydrates
TKM Shing et al.
JOURNAL OF ORGANIC CHEMISTRY (2006)
Wortmannin-C20 conjugates generate wortmannin
HS Yuan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Oncogenic PI3K deregulates transcription and translation
AG Bader et al.
NATURE REVIEWS CANCER (2005)
A convenient oxazole C-2 protecting group: The synthesis of 4-and 5-substituted oxazoles via metalation of 2-triisopropylsilyloxazoles
RA Miller et al.
JOURNAL OF ORGANIC CHEMISTRY (2005)
Formal total synthesis of (+)-wortmannin using catalytic asymmetric intramolecular aldol condensation reaction
H Shigehisa et al.
TETRAHEDRON (2005)
Concise synthesis of the plant growth regulator theobroxide
H Arimoto et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2005)
PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors
K Yu et al.
CANCER BIOLOGY & THERAPY (2005)
Synthesis and activity of C11-modified wortmannin probes for P13 kinase
HS Yuan et al.
BIOCONJUGATE CHEMISTRY (2005)
Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase
YS Liu et al.
CHEMISTRY & BIOLOGY (2005)
Chemistry and biology of wortmannin
P Wipf et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2005)
In vitro metabolism of the phosphatidylinositol 3-kinase inhibitor, wortmannin, by carbonyl reductase
JL Holleran et al.
DRUG METABOLISM AND DISPOSITION (2004)
Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin
P Wipf et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2004)
Synthesis of the furanosteroidal antibiotic viridin
EA Anderson et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2004)
Palladium-catalyzed oxidative carbonylation of 1-alkynes into 2-alkynoates with molecular oxygen as oxidant
Y Izawa et al.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN (2004)
Use of high-performance liquid chromatography to characterize the rapid decomposition of wortmannin in tissue culture media
JL Holleran et al.
ANALYTICAL BIOCHEMISTRY (2003)
Ketone synthesis under neutral conditions. Cu(I) diphenylphosphinate-mediated, palladium-catalyzed coupling of thiol esters and organostannanes
R Wittenberg et al.
ORGANIC LETTERS (2003)
The asymmetric intramolecular Heck reaction in natural product total synthesis
AB Dounay et al.
CHEMICAL REVIEWS (2003)
Structure reassignment of the fungal metabolite TAEMC161 as the phytotoxin viridiol
P Wipf et al.
JOURNAL OF NATURAL PRODUCTS (2003)
The Wacker reaction and related alkene oxidation reactions
JM Takacs et al.
CURRENT ORGANIC CHEMISTRY (2003)
Studies on the sequential multi-component coupling/Diels-Alder cycloaddition reaction
DL Wright et al.
TETRAHEDRON LETTERS (2002)
Total synthesis of (+/-)-Wortmannin
T Mizutani et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2002)
Heterolignanolides, Furo- and thieno-analogues of podophyllotoxin and thuriferic acid
AC Ramos et al.
TETRAHEDRON (2001)
Halenaquinone, a novel phosphatidylinositol 3-kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells
H Fujiwara et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2001)
Approaches to the synthesis of (+)- and (-)-epibatidine
MT Barros et al.
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 (2001)
A new inhibitor of 5′-hydroxyaverantin dehydrogenase, an enzyme involved in aflatoxin biosynthesis, from Trichoderma hamatum
E Sakuno et al.
JOURNAL OF NATURAL PRODUCTS (2000)
Asymmetric synthesis of the fully functional macrolide core of salicylihalamide:: Remote control of olefin geometry during RCM
A Fürstner et al.
ORGANIC LETTERS (2000)
New construction of ortho ring-alkylated phenols via generation and reaction of assorted o-quinone methides
RW Van de Water et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
Total syntheses of (±)- and (-)-stemoamide
PA Jacobi et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
Wortmannin inhibits activation of nuclear transcription factors NF-κB and activated protein-1 induced by lipopolysaccharide and phorbol ester
SK Manna et al.
FEBS LETTERS (2000)
PI3-kinase inhibition: a target for drug development?
RC Stein et al.
MOLECULAR MEDICINE TODAY (2000)