期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 19, 期 26, 页码 5788-5793出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob00863c
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资金
- National Research Foundation (NRF) of Korea [2021R1A2C1003804]
- National Research Foundation of Korea [2021R1A2C1003804] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This paper reports the synthesis of two deoxyuridine derivatives functioning as molecular rotors, and demonstrates the utility of this probing system in sensing gene regulation arising from interactions between G-quadruplex and nucleolin.
In this paper we report the synthesis of two deoxyuridine derivatives (dU(CN2), dU(Py))-featuring p-vinylaniline-based fluorophores linked through a propargyl unit at the 5' position- that function as molecular rotors. This probing system proved to be useful for the sensing of gene regulation arising from interactions between this G-quadruplex and nucleolin.
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