A copper iodide-catalyzed coupling reaction of benzofuran-3(2H)-ones with amines: an approach to α-ketoamides

A CuI-catalyzed coupling reaction of benzofuran-3(2H)-ones with amines has been well established for the direct synthesis of alpha-ketoamides. This process involves C-O bond cleavage and CvO/C-N bond formation. Mechanism studies indicated that this alpha-ketoamide formation reaction may involve a free radical process.

Automated summary

The CuI-catalyzed coupling reaction of benzofuran-3(2H)-ones with amines allows for the direct synthesis of alpha-ketoamides, involving C-O bond cleavage and C=O/C-N bond formation. Mechanistic studies suggest that this reaction may proceed through a free radical process.