期刊
EMERGING INFECTIOUS DISEASES
卷 27, 期 5, 页码 1371-1379出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2705.204490
关键词
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资金
- Federal Ministry of Education and Research within the Zoonotic Bornavirus Consortium
- National Network of Zoonotic Infectious Diseases in Germany [01KI2005C]
This study investigated bornavirus etiology of encephalitis cases in Germany, identifying 4 cases related to variegated squirrel bornavirus and Borna disease virus through serological testing. These infections caused by the two viruses are severe and often fatal, especially in virus-endemic areas and with animal exposure.
Human bornavirus encephalitis is a severe and often fatal infection caused by variegated squirrel bornavirus 1 (VSBV-1) and Borna disease virus 1 (BoDV-1). We conducted a prospective study of bornavirus etiology of encephalitis cases in Germany during 2018-2020 by using a serologic testing scheme applied along proposed graded case definitions for VSBV-1, BoDV-1, and unspecified bornavirus encephalitis. Of 103 encephalitis cases of unknown etiology, 4 bornavirus infections were detected serologically. One chronic case was caused by VSBV-1 after occupational-related contact of a person with exotic squirrels, and 3 acute cases were caused by BoDV-1 in virus-endemic areas. All 4 case-patients died. Bornavirus etiology could be confirmed by molecular methods. Serologic testing for these cases was virus specific, discriminatory, and a practical diagnostic option for living patients if no brain tissue samples are available. This testing should be guided by clinical and epidemiologic suspicions, such as residence in virus-endemic areas and animal exposure.
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