4.7 Article

Structure-activity relationship of avocadyne

期刊

FOOD & FUNCTION
卷 12, 期 14, 页码 6323-6333

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1fo00693b

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资金

  1. NIH [AI154860, R01-DK78755]
  2. Cancer Research Society
  3. NSERC
  4. Ontario Institute for Cancer Research
  5. Hass Avocado Board

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This study conducted a structure-activity analysis on avocadyne, identifying specific structural features critical to suppressing mitochondrial fatty acid oxidation.
Avocado consumption is associated with numerous health benefits. Avocadyne is a terminally unsaturated, 17-carbon long acetogenin found almost exclusively in avocados with noted anti-leukemia and anti-viral properties. In this study, specific structural features such as the terminal triple bond, odd number of carbons, and stereochemistry are shown to be critical to its ability to suppress mitochondrial fatty acid oxidation and impart selective activity in vitro and in vivo. Together, this is the first study to conduct a structure-activity analysis on avocadyne and outline the chemical moieties critical to fatty acid oxidation suppression.

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