期刊
BIOMEDICAL JOURNAL
卷 44, 期 2, 页码 115-122出版社
ELSEVIER
DOI: 10.1016/j.bj.2020.10.001
关键词
Innate lymphoid cells; Natural killer cells; ILC1; Interferon (IFN)-gamma; Host protection; Immunomodulation
资金
- JSPS KAKENHI [JP16H06387, 18H05022]
- Naito Foundation
- Kato Memorial Bioscience Foundation
- Life Science Foundation of Japan
- Uehara Memorial Foundation
- Kanae Foundation for the Promotion of Medical Science
- Grants-in-Aid for Scientific Research [18H05022] Funding Source: KAKEN
Innate lymphoid cells (ILCs) play vital roles in host protection and immune modulation, with ILC1s producing cytokines against pathogens and promoting tissue protection and metabolism.
Innate lymphoid cells (ILCs) are tissue-resident innate lymphocytes that have functions to protect the hosts against pathogens and that regulate tissue inflammation and homeostasis. ILC subsets rapidly produce particular cytokines in response to infection, inflammation, and tissue injury at the local environment. Type 1 ILCs (ILC1s) promptly and abundantly produce interferon (IFN)-gamma but lack appreciable cytotoxic activity. ILC1s share many phenotypic, developmental, and functional characteristics with natural killer (NK) cells, which are circulating innate lymphocytes with potent natural cytotoxicity. However, recent studies have established ILC1s as distinct from NK cells. ILC1s predominantly reside in the liver-they initially were discovered as a liver-resident ILC subsetdas well as in other lymphoid and non-lymphoid tissues. Accumulating evidence has demonstrated that ILC1s play an important and unique role in host protection and in immunomodulation in their resident organs. However, the pathophysiological role of tissue-resident ILC1s remains largely unclear. In this review, we summarize emerging evidence showing that ILC1s not only contribute to inflammation to protect against pathogens but also promote tissue protection and metabolism. We highlight a unique function of ILC1s in their resident tissues.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据