The many roles of myosins in filopodia, microvilli and stereocilia

Filopodia, microvilli and stereocilia represent an important group of plasma membrane protrusions. These specialized projections are supported by parallel bundles of actin filaments and have critical roles in sensing the external environment, increasing cell surface area, and acting as mechanosensors. While actin-associated proteins are essential for actin-filament elongation and bundling in these protrusions, myosin motors have a surprising role in the formation and extension of filopodia and stereocilia and in the organization of microvilli. Actin regulators and specific myosins collaborate in controlling the length of these structures. Myosins can transport cargoes along the length of these protrusions, and, in the case of stereocilia and microvilli, interactions with adaptors and cargoes can also serve to anchor adhesion receptors to the actin-rich core via functionally conserved motor-adaptor complexes. This review highlights recent progress in understanding the diverse roles myosins play in filopodia, microvilli and stereocilia.

Automated summary

Filopodia, microvilli, and stereocilia are important plasma membrane protrusions supported by actin filaments, playing critical roles in sensing the environment and increasing cell surface area. Actin regulators and specific myosins collaborate to control the length of these structures and transport cargoes along the protrusions. Myosin motors also play surprising roles in the formation and extension of these protrusions.