Relationship Between Gonadal Hormone Levels and Symptom Severity in Female Patients With Schizophrenia

Objective: It is thought that sex-specific differences in schizophrenia may be associated with gonadal hormones, especially estrogen.Th is study aimed to investigate the relationship between follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, estradiol, and progesterone serum levels and symptom severity during the menstrual cycle in female patients with schizophrenia. Methods: Serum samples were taken in the follicular and periovulatory phases from 32 female patients with schizophrenia; and FSH, LH, prolactin, estradiol, and progesterone levels were performed. Simultaneously, the patients were administered positive and negative symptom scale (PANSS), Calgary depression scale for schizophrenia (CDSS), and Hamilton anxiety rating scale (HAM-A). Results: PANSS (z = -2.52, P < .001), HAM-A (z = -3.60, P < .001), and CDSS (z = -2.52, P = .012) scores were lower in the periovulatory phase than in the follicular phase. Negative correlations between FSH and PANSS positive symptom subscale (r = -0393, P = .035), and between prolactin and PANSS total score (r = -0.406, P= .029) were detected. Conclusion: Hypoestrogenism should be studied more in patients with schizophrenia. Studies with large samples evaluating FSH, LH, prolactin, and progesterone together with estrogen are needed to be able to safely use gonadal hormones, which may be related to schizophrenia symptom severity, especially in patients who do not respond adequately to treatment.

Automated summary

This study investigated the relationship between hormone levels in the menstrual cycle and symptom severity in female patients with schizophrenia. It found that symptom scores were lower in the periovulatory phase, and negative correlations were observed between FSH and positive symptoms, as well as between prolactin and total symptoms score. Further research with larger samples is needed to explore the potential impact of gonadal hormones on schizophrenia.