期刊
EXPERT REVIEWS IN MOLECULAR MEDICINE
卷 19, 期 -, 页码 -出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/erm.2017.8
关键词
-
资金
- EU-FP7 P-medicine project [270089]
- EU-FP7 project European Network for Cancer research in Children and Adolescents (ENCCA) [261474]
- Cancer Research UK, [C1188/A4614]
- Great Ormond Street Hospital Children's Charity
- Children with Cancer
- NIHR GOSH UCL Biomedical Research Centre
- Association Leon Berard Enfant Cancereux (ALBEC) charity
- Cancer Research UK [17297] Funding Source: researchfish
- Great Ormond Street Hospital Childrens Charity [W1090, V1405] Funding Source: researchfish
Wilms tumour (WT) is the most common paediatric kidney cancer and affects approximately one in 10 000 children. The tumour is associated with undifferentiated embryonic lesions called nephrogenic rests (NRs) or, when diffuse, nephroblastomatosis. WT or NRs can occur in both kidneys, termed bilateral disease, found in only 5-8% of cases. Management of bilateral WT presents a major clinical challenge in terms of maximising survival, preserving renal function and understanding underlying genetic risk. In this review, we compile clinical data from 545 published cases of bilateral WT and discuss recent progress in understanding the molecular basis of bilateral WT and its associated precursor NRs in the context of the latest radiological, surgical and epidemiological features.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据