期刊
CHEMICAL SOCIETY REVIEWS
卷 50, 期 13, 页码 7820-7880出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cs00729c
关键词
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资金
- Engineering and Physical Sciences Research Council [EP/P020291/1]
- Royal Society (Wolfson Research Merit Award)
- EPSRC [EP/P020291/1] Funding Source: UKRI
Bacterial infections caused by 'superbugs' are on the rise globally, with traditional antibiotics becoming less effective, posing a risk of entering a post-antibiotic era. Antimicrobial peptides (AMPs) have garnered attention for their clinical potential as a new class of antibiotics to combat antimicrobial resistance. This review discusses various aspects of AMPs, including their physicochemical properties, mechanisms of action, and chemical synthesis strategies for developing novel AMPs.
Bacterial infections caused by 'superbugs' are increasing globally, and conventional antibiotics are becoming less effective against these bacteria, such that we risk entering a post-antibiotic era. In recent years, antimicrobial peptides (AMPs) have gained significant attention for their clinical potential as a new class of antibiotics to combat antimicrobial resistance. In this review, we discuss several facets of AMPs including their diversity, physicochemical properties, mechanisms of action, and effects of environmental factors on these features. This review outlines various chemical synthetic strategies that have been applied to develop novel AMPs, including chemical modifications of existing peptides, semi-synthesis, and computer-aided design. We will also highlight novel AMP structures, including hybrids, antimicrobial dendrimers and polypeptides, peptidomimetics, and AMP-drug conjugates and consider recent developments in their chemical synthesis.
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