4.2 Article

Upconversion Luminescent Nanostructure with Ultrasmall Ceramic Nanoparticles Coupled with Rose Bengal for NIR-Induced Photodynamic Therapy

期刊

ACS APPLIED BIO MATERIALS
卷 4, 期 5, 页码 4462-4469

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsabm.1c00213

关键词

rare-earth-doped ceramics; upconversion; ultrasmall nanoparticles; hydrocabonized rose bengal; biodegradable polymer; theranostics

资金

  1. MEXT [15H05950, 19H01179]
  2. Center of Innovation Program COINS from Japan Science and Technology Agency (JST) of Japan
  3. MOST of Taiwan [107-2221-E007-032-MY3]
  4. Grants-in-Aid for Scientific Research [19H01179] Funding Source: KAKEN

向作者/读者索取更多资源

A biodegradable hybrid nanostructure for NIR-induced photodynamic therapy was designed, utilizing ultrasmall upconversion phosphor and hydrocarbonized rose bengal dye encapsulated in a micelle. The structure efficiently emitted green UC luminescence and released singlet oxygen to surrounding water, degrading through hydrolysis of PEG-b-PCL for potential clinical use in deep tissue cancer PDT.
We designed a biodegradable hybrid nanostructure for near-infrared (NIR)-induced photodynamic therapy (PDT) using an ultrasmall upconversion (UC) phosphor (beta-NaYF4:Yb3+, Er3+ nanoparticle: NPs) and a hydrocarbonized rose bengal (C18RB) dye, a hydrophobized rose bengal (RB) derivative. The UC-NPs were encapsulated along with C18RB in the hydrophobic core of the micelle composed of poly(ethylene glycol) (PEG)-block-poly(epsilon-caprolactone) (PCL). The UC-NPs were well shielded from the aqueous environment, owing to the encapsulation in the hydrophobic PCL core, to efficiently emit green UC luminescence by avoiding the quenching by the hydroxyl groups. The hydrophobic part of C-18 of C18RB worked well to be involved in the PCL core and located RB on the surface of the PCL core, making the efficient absorption of green light and the emission of singlet oxygen to surrounding water possible. Moreover, as the location is covered by PEG, the direct contact of RB to cells is prohibited to avoid their irradiation-free toxic effect on the cells. The hybrid nanostructure proved to be degradable by the hydrolysis of PEG-b-PCL. This degradation potentially results in renal excretion by the decomposition of the nanostructure into sub-10 nm size particles and makes them viable for clinical uses. These nanostructures can potentially be used for PDT of cancer in deep tissues.

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