4.8 Article

Central anorexigenic actions of bile acids are mediated by TGR5

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MOLECULAR PHYSIOLOGY OF BILE ACID SIGNALING IN HEALTH, DISEASE, AND AGING

Alessia Perino et al.

Summary: Bile acids have become important signaling molecules in the body, enabling inter-tissue communication and exerting pleiotropic physiological effects. The chemical variety of bile acids, largely determined by the gut microbiome, allows for complex adaptive responses in the body. This review discusses the mechanisms by which bile acid receptors coordinate various aspects of physiology and presents new therapeutic strategies for diseases related to pathological bile acid signaling.

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