期刊
FOOD AND AGRICULTURAL IMMUNOLOGY
卷 32, 期 1, 页码 310-320出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09540105.2021.1934418
关键词
Pollen allergy; itch; Grifola frondosa; ergosterol; leukotriene B-4; mast cells
资金
- Hokuto Corporation
Grifola frondosa and its active ingredient ergosterol prevent pollen allergy-induced itching by inhibiting leukotriene B-4 production in mast cells.
Grifola frondosa (G. frondosa) is an edible mushroom consumed as a health food in Asia that has recently been reported to have anti-allergic effects. In this study, we investigated the effects of G. frondosa on pollen allergy-induced ocular itching in mice. G. frondosa was boiled and freeze-dried (heat-treated G. frondosa). Oral administration of heat-treated G. frondosa (0.1 and 1 g/kg) suppressed pollen allergy-induced ocular itching and plasma extravasation but not histamine-induced plasma extravasation. Oral administration of ergosterol, an active ingredient in G. frondosa (5 and 50 mg/kg), or zileuton (100 mg/kg), which is an inhibitor of 5-lipoxygenase (the main enzyme required for leukotriene B-4 production), inhibited pollen allergy-induced ocular itching. In addition, ergosterol inhibited antigen-induced leukotriene B-4 production in mast cells. These findings suggest that G. frondosa and its active ingredient ergosterol prevent pollen allergy-induced itching through the inhibition of leukotriene B-4 production in mast cells. [GRAPHICS]
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