期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 17, 期 8, 页码 1979-1994出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.58422
关键词
LncRNA; SH3PXD2A-AS1; CRC; Metastasis; P53
资金
- National Natural Science Foundation of China [82002478, 81874183, 82072649, 81872304, 81672845]
- Outstanding Youth Foundation of Jiangsu Province [BK20201010, BK20200046]
- Science and Technology Project of Xuzhou [KC20100]
- National science research in Universities of Jiangsu Province [20KJB320031]
- Education Department of Jiangsu Province [19KJA130001]
- Jiangsu Provincial Key Medical Discipline
- Project of Invigorating Health Care through Science, Technology and Education [ZDXKA2016014]
- Qinglan Project of Jiangsu
This study identified SH3PXD2A-AS1 as highly overexpressed in colorectal cancer (CRC), promoting cell proliferation, angiogenesis, and metastasis by directly interacting with p53 protein to regulate p53-mediated gene transcription. These findings suggest SH3PXD2A-AS1 as a potential prognostic biomarker and therapeutic target for CRC clinical management.
Long non-coding RNAs (lncRNAs) play key roles in various human cancers. We aimed to determine the key lncRNAs mediating colorectal cancer (CRC) progression. We identified some lncRNAs aberrantly expressed in CRC tissues by using lncRNA microarrays and demonstrated that SH3PXD2A-AS1 was one of the most highly overexpressed lncRNAs in CRC. We further aimed to explore the roles and possible molecular mechanisms of SH3PXD2A-AS1 in CRC. RNA ISH revealed that SH3PXD2A-AS1 was overexpressed in CRC compared with adjacent normal colon tissues and indicated poor prognosis in CRC. Functional analyses showed that SH3PXD2A-AS1 enhanced cell proliferation, angiogenesis, and metastasis. Mechanistically, SH3PXD2A-AS1 can directly interact with p53 protein and regulate p53-mediated gene transcription in CRC. We provided mechanistic insights into the regulation of SH3PXD2A-AS1 on p53-mediated gene transcription and suggested its potential as a new prognostic biomarker and target for the clinical management of CRC.
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