Exfoliated FePS3 nanosheets for T1-weighted magnetic resonance imaging-guided near-infrared photothermal therapy in vivo

Developing bifunctional nanoplatforms integrating advanced biological imaging with high-performance therapeutic functions is interesting for nanoscience and biomedicine. Herein, thin-layered FePS3 nanosheets modified with amine polyethylene glycol (FePS3-PEG) are synthesized by ultrasonicated exfoliation of bulk FePS3 single crystals under Ar atmosphere and in situ chemical functionalization with amine PEG. The prepared FePS3-PEG nanosheets give a photothermal conversion efficiency of 22.1% under 808-nm laser and evident T-1 relaxation (r(1) = 2.69 (mmol L-1)(-1) S-1) in external magnetic fields. Biologically experimental results in vitro and in vivo demonstrate that FePS3-PEG nanosheets have good biocompatibility and exhibit excellent photothermal therapy (PTT) effect under clear T-1 weighted magnetic resonance imaging (MRI). The characteristics of FePS3-PEG nanosheets enable them to be a promising nanomedicine for T-1-weighted MRI-guided near-infrared PTT of cancers.

Automated summary

The study successfully synthesized FePS3-PEG nanosheets with excellent photothermal conversion efficiency and magnetic resonance imaging effects, making them promising for T-1 weighted MRI-guided near-infrared photothermal therapy for cancer treatment.