期刊
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
卷 15, 期 7, 页码 703-711出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14787210.2017.1349609
关键词
Respiratory microbiome; lower respiratory tract infections; pneumonia; bronchiolitis; asthma; next-generation sequencing; 16S rRNA
资金
- Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) [UID/Multi/04413/2013]
- Plan Nacional de I+D+I
- Instituto de Salud Carlos III- Subdireccion General de Evaluacion y Fomento de la Investigacion Sanitaria [PI16/00174]
- European Regional Development Fund (FEDER)
Introduction: The respiratory airways harbor a complex succession of ecological niches with distinct but related bacterial communities. Particular challenges of respiratory microbiome research have led to limited scientific output compared to other human microbiomes.Areas covered: In this review, we summarize the current state of knowledge of the bacterial respiratory microbiome, with a particular focus on associations between the respiratory microbiome and lower respiratory tract conditions.Expert commentary: There is growing evidence that the respiratory microbiome is associated with lower respiratory infectious diseases and related conditions. Most respiratory microbiome reports are metataxonomic cross-sectional or case-control studies with relatively small sample sizes. Large, prospective projects with metatranscriptomics or metabolomics approach are needed to unravel the effect of the respiratory microbiome on health-related conditions. Moreover, standardization in sampling, library preparation, sequencing techniques and data analysis should be encouraged.
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