Advances in Deallylation

Allyl groups, as a kind of universal protective groups in organic synthesis, are easily introduced, and stable under acidic, basic and reductive conditions. Moreover, the deallylation may occur efficiently and selectively under mild conditions. Therefore, functional group protection with allyl moiety plays a significant role in organic synthesis, especially in the synthesis of natural products and pharmaceutical industry. In recent decades, various methods of deallylation have been developed. Herein, the comprehensive development on the deallylation reaction with base and reductant, oxidation and free radical, Lewis-acid, iodine, transition metals, and electrochemical methods is reviewed.

Automated summary

Allyl groups serve as versatile protective groups in organic synthesis, being stable under various conditions and easily removed under mild conditions. They play a significant role in the synthesis of natural products and pharmaceutical industry. Various methods of deallylation have been developed in recent decades.