期刊
RSC ADVANCES
卷 11, 期 31, 页码 18748-18756出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ra00997d
关键词
-
资金
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [390713860, 239748522]
- European Research Council [ERC-CoG - 771349]
- Danish Council for Independent Research [DFF - 7014-00178]
- Humboldt Foundation
Targeted metabolomic analysis of Pseudoxylaria sp. X187 identified two new lipopeptidic congeners, xylacremolides C and D, which showed weak histone deacetylase inhibitory and antifungal activities, as well as moderate protease inhibition activity against a panel of nine human, viral, and bacterial proteases. A putative xy gene cluster was identified from draft genome data generated by Illumina and PacBio sequencing, along with RNAseq studies.
Targeted HRMS2-GNPS-based metabolomic analysis of Pseudoxylaria sp. X187, a fungal antagonist of the fungus-growing termite symbiosis, resulted in the identification of two lipopeptidic congeners of xylacremolides, named xylacremolide C and D, which are built from d-phenylalanine, l-proline and an acetyl-CoA starter unit elongated by four malonyl-CoA derived ketide units. The putative xya gene cluster was identified from a draft genome generated by Illumina and PacBio sequencing and RNAseq studies. Biological activities of xylacremolide A and B were evaluated and revealed weak histone deacetylase inhibitory (HDACi) and antifungal activities, as well as moderate protease inhibition activity across a panel of nine human, viral and bacterial proteases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据