Coarse-grained nucleic acid-protein model for hybrid nanotechnology

The emerging field of hybrid DNA-protein nanotechnology brings with it the potential for many novel materials which combine the addressability of DNA nanotechnology with the versatility of protein interactions. However, the design and computational study of these hybrid structures is difficult due to the system sizes involved. To aid in the design and in silico analysis process, we introduce here a coarse-grained DNA/RNA-protein model that extends the oxDNA/oxRNA models of DNA/RNA with a coarse-grained model of proteins based on an anisotropic network model representation. Fully equipped with analysis scripts and visualization, our model aims to facilitate hybrid nanomaterial design towards eventual experimental realization, as well as enabling study of biological complexes. We further demonstrate its usage by simulating DNA-protein nanocage, DNA wrapped around histones, and a nascent RNA in polymerase.

Automated summary

The emerging field of hybrid DNA-protein nanotechnology shows promise for novel materials, but faces challenges in design and computational study. A coarse-grained DNA/RNA-protein model is introduced to aid in design and analysis, with the goal of facilitating hybrid nanomaterial design and enabling study of biological complexes.