Cultured cell-derived decellularized extracellular matrix (cultured cell-derived dECM): Future applications and problems - a mini review

Extracellular matrix (ECM) is a key component of applications in many bioengineering fields, including tissue engineering and regenerative medicine because ECM can regulate various cell functions. There is substantial interest in the reconstruction of native ECM. For ECM reconstruction, a decellularization technique is usually used. ECM sources for ECM reconstruction by decellularization are classified into two groups: tissue-/organ-derived ECM and ECM formed by cultured cells. Although tissue- or organ-derived decellularized ECM (dECM) is well studied and many tissue-/organ-derived dECM are commercially available, most cultured cell-derived dECM remains experimental. This review provides a brief comparison between cultured cell-derived dECM and tissue-/organ-derived dECM and summarizes the effects of cultured cell-derived dECM on cell function. In addition, it provides a discussion of the future applications of dECM and the potential challenges they face.

Automated summary

Extracellular matrix (ECM) is crucial in bioengineering applications such as tissue engineering and regenerative medicine for regulating cell functions. Decellularization technique is commonly used for ECM reconstruction, with sources classified into tissue/organ-derived and cultured cell-derived ECM. While tissue/organ-derived decellularized ECM is well studied and commercially available, cultured cell-derived ECM remains mostly experimental.