C-H activation

Transition metal-catalysed C-H activation has emerged as an increasingly powerful platform for molecular syntheses, enabling applications to natural product syntheses, late-stage modification, pharmaceutical industries and material sciences, among others. This Primer summarizes representative best practices for the experimental set-up and data deposition for C-H activation, as well as discussing key developments including recent advances in asymmetric, photoinduced and electrocatalytic C-H activation. Likewise, strategies for applications of C-H activation towards the assembly of structurally complex (bio)polymers and drugs in academia and industry are discussed. In addition, current limitations in C-H activation and possible approaches for overcoming these shortcomings are reviewed.

Automated summary

C-H activation has emerged as a powerful platform for molecular syntheses in various fields including natural product syntheses, pharmaceutical industries, and material sciences. This Primer summarizes best practices for experimental set-up, data deposition, and key developments in C-H activation, as well as discussing its applications and limitations.