期刊
CLINICAL OPHTHALMOLOGY
卷 15, 期 -, 页码 2167-2178出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OPTH.S259011
关键词
presbyopia; epidemiology; patient characterization; vision correction; pharmacological therapies
资金
- Novartis Pharma AG, Basel, Switzerland
Presbyopia is a common age-related vision disorder that can significantly impact quality of life if left untreated. Current corrective methods, such as progressive or bifocal spectacles, contact lenses, and surgical interventions, have limitations and may not provide long-lasting solutions for presbyopic individuals. There is a need for more effective and non-invasive treatment options for presbyopia to address the significant gaps in vision correction for this condition.
Presbyopia is a common age-related vision disorder characterized by a progressive inability to focus on near objects. If uncorrected or under-corrected, presbyopia can significantly impact patients' quality of life. Presbyopia represents an area of considerable unmet need due to its rising prevalence worldwide as the population ages, the high proportion of under-treated individuals in some parts of the world, and the limitations of currently available corrective methods. Progressive or bifocal spectacles are associated with peripheral blur, a restricted visual field and impaired depth perception, which have been linked to an increased risk of falls in the elderly. Contact lens options can be difficult to maintain due to the development of age-related dry eye symptoms and reduced manual dexterity. Other corrective methods involve surgical interventions that modify the optics of the cornea, replace the crystalline lens, or attempt to restore active accommodation. While patients undergoing surgery report satisfactory outcomes post-operatively, many of them eventually require reading glasses. Non-invasive therapies with novel mechanisms of action are currently being investigated; these include miotic agents and UNR844, a lipoic acid choline ester. In this narrative review, available evidence on presbyopia prevalence, quality of life impact and risk factors are described, with a focus on observational studies in nonclinical settings. The diagnosis pathway and patient journey in presbyopia are outlined, and various treatment options are analyzed. The data reviewed herein reveals significant gaps in the provision of vision correction for this common condition, with a paucity of effective, non-invasive treatment options broadly accessible to presbyopic individuals.
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