期刊
ANNALS OF TRANSLATIONAL MEDICINE
卷 9, 期 10, 页码 -出版社
AME PUBL CO
DOI: 10.21037/atm-21-1162
关键词
Electrocardiograph gating (ECG); atrial septum (AS); ventricular septum (VS); margin; internal risk volume (IRV)
This study quantified the margin of internal risk volume (IRV) on the atrial septum (AS) and ventricular septum (VS) based on ECG-gating 4DCT, finding that the margins could cover the movement of AS and VS induced by heartbeat in three directions. The emendatory margins significantly improved the coverage rates.
Background: The aim of this study was to quantify the margin of internal risk volume (IRV) on the atrial septum (AS) and ventricular septum (VS) based on electrocardiograph gating (ECG-gating) 4DCT. Methods: Twenty patients were enrolled and received an ECG-gating 4DCT scan performed in breath-hold, and CT images were reconstructed at 5% intervals of the cardiac cycle for a total of 20 phases (0-95%). The contouring of the AS and VS were delineated in each phase, and the displacements and margin of the AS and VS were calculated. We fused the total of the AS and VS (0-95% phase), which were recorded as AS(20) and VS20. The margins were applied to the AS and VS in every phase and revised according to the cover rate of AS(20) and VS20. Results: (I) The margins of the AS and VS according to displacements in the left-right, cranio-caudal, and antero-posterior direction were 3 mm, 3 mm, and 3 mm; and 3 mm, 3 mm, and 2 mm, respectively. (II) The volume of AS(20) was (11.80 +/- 3.72) cm(3), which was 2.9 times larger than the maximum volume of the AS. The volume of VS20 was (60.45 +/- 12.92) cm(3), which was 1.6 times larger than the maximum volume of the VS. (III) The emendatory margins of the AS and VS in the left-right, cranio-caudal, and antero-posterior direction were 7 mm, 10 mm, and 7 mm; and 5 mm, 3 mm, and 4 mm, respectively. The emendatory margins were added to the AS and VS, and the coverage rates were (95.88 +/- 3.29)% and (95.24 +/- 2.54)%, respectively. Conclusions: The margin of IRV on the AS and VS could cover the movement of AS and VS induced by heartbeat in the left-right, cranio-caudal, and antero-posterior direction respectively during thoracic radiotherapy.
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