期刊
JOURNAL OF CLINICAL MEDICINE
卷 10, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/jcm10112296
关键词
OCTA; diabetes; retinopathy; severity; ischemia
资金
- AIBILI
- COMPETE Portugal2020
- Fundo de Inovacao, Tecnologia e Economia Circular (FITEC)-Programa Interface [FITEC/CIT/2018/2]
A three-year observational study on individuals with type 2 diabetes found a correlation between retinal vessel closure and the severity progression of diabetic retinopathy. The study showed that retinal vessel density was significantly associated with worsening retinopathy, indicating that OCTA metrics of vessel closure may be used as a surrogate for diabetic retinopathy severity progression. However, no clear correlation was found between neurodegenerative changes and retinopathy progression.
BackgroundTo examine retinal vessel closure metrics and neurodegenerative changes occurring in the initial stages of nonproliferative diabetic retinopathy (NPDR) and severity progression in a three-year period. Methods: Three-year prospective longitudinal observational cohort of individuals with type 2 diabetes (T2D), one eye per person, using spectral domain-optical coherence tomography (SD-OCT) and OCT-Angiography (OCTA). Eyes were examined four times with one-year intervals. OCTA vessel density maps of the retina were used to quantify vessel closure. Thickness of the ganglion cell + inner plexiform layer (GCL + IPL) was examined to identify retinal neurodegenerative changes. Diabetic retinopathy ETDRS classification was performed using the seven-field ETDRS protocol. Results: A total of 78 eyes/patients, aged 52 to 80 years, with T2D and ETDRS grades from 10 to 47 were followed for 3 years with annual examinations. A progressive increase in retinal vessel closure was observed. Vessel density (VD) showed higher decreases with retinopathy worsening demonstrated by step-changes in ETDRS severity scale (p < 0.001). No clear correlation was observed between neurodegenerative changes and retinopathy progression. Conclusions: Retinal vessel closure in NPDR correlates with DR severity progression. Our findings provide supporting evidence that OCTA metrics of vessel closure may be used as a surrogate for DR severity progression.
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