期刊
EXPERIMENTAL PARASITOLOGY
卷 183, 期 -, 页码 76-80出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2017.10.012
关键词
Tunisian seaweeds; Biological activity; Antiparasitic activity; Acanthamoeba; Antioxidant capacity
类别
资金
- grants RICET of the programme of Redes Tematicas de Investigacion Cooperativa, FIS [RD06/0021/0005]
- Spanish Ministry of Health, Madrid, Spain
- Project Protozoosis emergentes por amebas de vida libre: aislamiento y caracterizacion molecular, identificacion de cepas transportadoras de otros agentes patogenos y busqueda de quimioterapias efectivas [FIS PI10/01298]
- Protozoosis Emergentes por Amebas de Vida Libre: Aislamiento, Caracterizacion, Nuevas Aproximaciones Terapeuticas y Traslacion Clinica de los Resultados from the Instituto de Salud Carlos III [PI13/00490]
- University of Carthage, Tunisian Ministry of Higher Education and Scientific Research
- University of La Laguna Ayudas para estancias de estudiantes de posgrado e investigadores y/o docents
- Agustin de Betancourt Programme
- Ayudas Proyectos Puente de la Universidad de La Laguna
Free-living amoebae of genus Acanthamoeba are opportunistic pathogens widely distributed in the environment, and are the causative agents of several humans' infections, such as Acanthamoeba keratitis, Granulomatous Amoebic Encephalitis and also disseminated infections. The existence of the cyst stage complicates Acanthamoeba therapy as it is highly resistant to antibiotics and physical agents. All these facts reinforced the necessity to find and develop an effective therapy against Acanthamoeba infections. In the present study, we are interested to several seaweeds species collected from the Tunisian coasts and belonging to the 3 phyla (brown, green and red algae). The aim was to quantify the Total Phenolic Compounds in different organic extract, to evaluate antioxidant capacity (DPPH and ABTS) and to study the antiprotozoal activity against A. castellanii Neff. The parasites have been inhibited by all extracts with an IC50 ranged from 52,3 +/- 1.8 mu g/mL for ethyl acetate extract, to 134,6 +/- 0.7 mu g/mL for the hexanic one for the various species studied. (C) 2017 Published by Elsevier Inc.
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