Preparation and characterization of Terminalia bellerica loaded PCL nanofibrous mats for biomedical applications

Wounds are big challenges to the wound care professionals. Topical wound care products and wound dressings are evolved every day. Advanced dressings are produced by incorporating antimicrobial agents, growth factors and herbal extracts to enhance the wound healing process. Nanofibres are the recent focus as drug delivery vehicle for the delivery of drugs to the target site. The aim of the study is to prepare Terminalia bellerica loaded PCL nanofibrous mats by electrospinning and to characterize the nanofibres for biomedical applications. Terminalia bellerica is one of the ingredients of Triphala which play important role as rejuvenating agent. The increasing concentration of Terminalia loaded PCL nanofibrous mats shows increased fiber diameter, wettability and Water uptake property. The wettability of the PCL was decreased from 113.3 +/- 3.62 to 59.98 +/- 4.99, 44.96 +/- 7.04 and 34.34 +/- 3.45 respectively for the Terminalia loaded PCL nanofibres. The 5% herbal loaded PCL nanofibrous mats shows antimicrobial activ-ity against gram negative bacteria. Further, Terminalia loaded PCL mats were found to be nontoxic and is responsible for the cell adhesion and proliferation and is useful as the potential candidate for wound dressing applications. (c) 2020 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the International Confer-ence on Mechanical, Electronics and Computer Engineering 2020: Materials Science.

Automated summary

The study focuses on incorporating Terminalia bellerica into PCL nanofibrous mats, which showed that increasing the concentration of Terminalia led to enhanced fiber diameter, wettability, and water uptake properties, as well as antimicrobial activity against gram-negative bacteria. This makes Terminalia-loaded PCL mats a potential candidate for wound dressing applications.