期刊
EXPERIMENTAL NEUROLOGY
卷 287, 期 -, 页码 348-357出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2016.04.011
关键词
Regeneration; Nerve; Outcome measures; Behavior; Functional recovery
资金
- Alberta Heritage for Medical Research [200400630]
- Alberta Innovates Health Solutions [201200859]
- Canadian Institute for Health Research [MOP8276]
- Canadian Institute for Health Research (CIHR) postdoctoral fellowship
- Alberta Innovates [201200859] Funding Source: researchfish
Traumatic peripheral nerve injuries are common and often result in partial or permanent paralysis, numbness of the affected limb, and debilitating neuropathic pain. Experimental animal models of nerve injury have utilized a diversity of outcome measures to examine functional recovery following injury. Four primary categories of outcome measures of regenerative success including retrograde labeling with counts of regenerating neurons, immunohistochemistry and histomorphometry, reinnervation of target muscles, and behavioral analysis of recovery will be reviewed. Validity of different outcome measures are discussed in context of hindlimb, forelimb, and facial nerve injury models. Severity of nerve injury will be highlighted, and comparisons between nerve crush injury and more severe transection and neuroma-in-continuity nerve injury paradigms will be evaluated. The case is made that specific outcome measures may be more sensitive to assessing functional recovery following nerve injury than others. This will be discussed in the context of the lack of association between certain outcome measures of nerve regeneration. Examples of inaccurate conclusions from specific outcome measures will also be considered. Overall, researchers must therefore take care to select appropriate outcome measures for animal nerve injury studies dependant on the specific experimental interventions and scientific questions addressed. (C) 2016 Elsevier Inc. All rights reserved.
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