4.5 Article

SERPINB10 contributes to asthma by inhibiting the apoptosis of allergenic Th2 cells

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A Genome-wide Association Study Identifies SERPINB10, CRLF3, STX7, LAMP3, IFNG-AS1, and KRT80 As Risk Loci Contributing to Cutaneous Leishmaniasis in Brazil

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Summary: This study identified 32 genomic loci associated with cutaneous leishmaniasis, with 6 most plausible genetic risk loci being SERPINB10, CRLF3, STX7, KRT80, LAMP3, and IENG-AS1. Several of these genes showed differential expression in CL biopsies compared to normal skin, with LAMP3, STX7, and CRLF3 being upregulated and KRT80 being downregulated. Cis-eQTLs across SERPINB10 mapped to chromatin interaction regions of different cell types, while those at IFNG-AS1 mapped to transcriptional/enhancer regions in T, natural killer, and B cells.

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