期刊
EXPERIMENTAL NEUROLOGY
卷 287, 期 -, 页码 384-394出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2016.02.007
关键词
Rehabilitation; Regeneration; Recovery; Spinal cord; Cortex; GDF10; TGF beta; Astrocyte; Behavior
资金
- American Stroke Association/Bugher Foundation UCLA Stroke Collaborative Research Center [NS085019, NS081055, NS077521, NS071481]
- Richard Merkin Foundation for Neural Repair at UCLA
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
Stroke is the leading cause of adult disability. Yet there is a limited degree of recovery in this disease. One of the mechanisms of recovery is the formation of new connections in the brain and spinal cord after stroke: post-stroke axonal sprouting. Studies indicate that post-stroke axonal sprouting occurs in mice, rats, primates and humans. Inducing post-stroke axonal sprouting in specific connections enhances recovery; blocking axonal sprouting impairs recovery. Behavioral activity patterns after stroke modify the axonal sprouting response. A unique regenerative molecular program mediates this aspect of tissue repair in the CNS. The types of connections that are formed after stroke indicate three patterns of axonal sprouting after stroke: reactive, reparative and unbounded axonal sprouting. These differ in mechanism, location, relationship to behavioral recovery and, importantly, in their prospect for therapeutic manipulation to enhance tissue repair. (C) 2016 Elsevier Inc. All rights reserved.
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