A double-locked probe for the detection of hydrogen sulfide in a viscous system

A novel double-locked probe, DCO-H2S-V, was prepared for detecting hydrogen sulfide in a highly viscous system. Experiments demonstrated that only when H2S and a high viscosity environment coexist in a cell, can the probe be activated effectively and emit fluorescence. This has been successfully used for detecting the changes in viscosity and H2S in a Parkinson's disease model, PC-12 cells treated with glutamate.

Automated summary

The novel double-locked probe DCO-H2S-V is able to detect hydrogen sulfide in highly viscous systems, demonstrating effective activation and fluorescence emission only when H2S and high viscosity coexist in a cell. It has successfully been used to detect changes in viscosity and H2S in a Parkinson's disease model.