期刊
EXPERIMENTAL HEMATOLOGY
卷 46, 期 -, 页码 9-20出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.exphem.2016.10.008
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资金
- National Institutes of Health (NIH) [1S10 RR027015-01]
- University of Cincinnati Millennium Scholars Fund
- Cincinnati Children's Hospital Research Foundation
Granulocyte colony-stimulating factor is a hematopoietic cytokine that stimulates neutrophil production and hematopoietic stem cell mobilization by initiating the dimerization of homodimeric granulocyte colony-stimulating factor receptor. Different mutations of CSF3R have been linked to a unique spectrum of myeloid disorders and related malignancies. Myeloid disorders caused by the CSF3R mutations include severe congenital neutropenia, chronic neutrophilic leukemia, and atypical chronic myeloid leukemia. In this review, we provide an analysis of granulocyte colony-stimulating factor receptor, various mutations, and their roles in the severe congenital neutropenia, chronic neutrophilic leukemia, and malignant transformation, as well as the clinical implications and some perspective on approaches that could expand our knowledge with respect to the normal signaling mechanisms and those associated with mutations in the receptor. Copyright (C) 2016 ISEH - International Society for Experimental Hematology. Published by Elsevier Inc.
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