期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 17, 期 9, 页码 2262-2277出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.60131
关键词
Circular RNA; N-6-methyladenosine (m(6)A); Biogenesis; M(6)A-modified circRNA; Pathophysiological processes
资金
- National Natural Science Foundation of China [11872134, 11672051]
- Natural Science Foundation of Chongqing, China [cstc2020jcyjmsxmX0035]
- sharing fund of Chongqing university's largescale equipment [202103150044]
circRNA, a type of non-coding RNA generated by a non-canonical splicing event, is highly influenced by m6A modification, which plays a crucial role in various pathophysiological processes. Understanding the regulatory mechanisms of m6A-modified circRNAs can lead to better insights into physiological mechanisms and the development of new biomarkers.
Circular RNA (circRNA) is a type of covalently closed and endogenous non-coding RNA (ncRNA) with tissueand cell-specific expression patterns generated by a non-canonical splicing event. Previous reports have indicated that circRNAs exert their functions in different ways, thereby participating in various pathophysiological processes. N6-methyladenosine (m6A) methylation occurs in the N6-position, which is the most abundant and conserved internal transcriptional modification in eukaryotes, including mRNA and ncRNAs. Accumulating evidences confirm that m6A modification also exists in the circRNA and greatly affects the biological functions of circRNA. Their dysregulated expression can be a cause of various pathophysiological processes, such as spermatogenesis, myoblast differentiation, cancer, cardiovascular disease, mental illness and so on. Understanding the role of m6A-modified circRNAs in pathophysiological processes may contribute to better understanding the physiological mechanisms and develop new biomarkers. This review summarizes the regulatory mechanism of m6A modification on circRNA metabolism and the role of m6A-modified circRNAs in pathophysiological processes. This article may pave the way for a better understanding of the role of epigenetically modified circRNAs in pathophysiological process.
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