Access to chiral γ-butenolides via palladium-catalyzed asymmetric allylic C-H alkylation of 1,4-dienes

Asymmetric allylic C-H alkylation of 1,4-pentadienes with alpha-angelica lactones has been developed by tri-axial phosphoramidite-palladium catalysis. This reaction can tolerate a range of functional groups under mild conditions, furnishing versatile chiral gamma,gamma-disubstituted butenolides in high yields with good to high levels of stereoselectivity.

Automated summary

The asymmetric allylic C-H alkylation of 1,4-pentadienes with alpha-angelica lactones has been successfully developed using tri-axial phosphoramidite-palladium catalysis. This reaction shows high yields and good to high levels of stereoselectivity under mild conditions, allowing for the formation of versatile chiral gamma,gamma-disubstituted butenolides.