Enantioselective fluorination of 3-indolinone-2-carboxylates with NFSI catalyzed by chiral bisoxazolines

A chiral Cu(i)-bisoxazoline complex catalyzed enantioselective electrophilic fluorination of 3-indolinone-2-carboxylates with NFSI has been accomplished to produce chiral 2-fluoro-3-indolinone-2-carboxylates in good yields with excellent enantioselectivities. This is the first report on the enantioselective fluorination of 2-substituted 3-indolinones using a chiral Cu(i)-bisoxazoline complex.

Automated summary

A chiral Cu(i)-bisoxazoline complex was used to catalyze the enantioselective electrophilic fluorination of 3-indolinone-2-carboxylates with NFSI, resulting in the production of chiral 2-fluoro-3-indolinone-2-carboxylates in good yields with excellent enantioselectivities. This marks the first report of enantioselective fluorination of 2-substituted 3-indolinones using a chiral Cu(i)-bisoxazoline complex.