期刊
EXPERIMENTAL GERONTOLOGY
卷 87, 期 -, 页码 139-147出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2016.04.011
关键词
Age; Activity; Sex Mouse; Wheel running
资金
- Deutsche Forschungsgemeinschaft [BA2077/4-1]
- Wilhelm Roux program at the Medical Faculty, Halle (Saale) [21/43]
Laboratory mice of both sexes having free access to running wheels are commonly used to study mechanisms underlying the beneficial effects of physical exercise on health and aging in human. However, comparative wheel-running activity profiles of male and female mice for a long period of time in which increasing age plays an additional role are unknown. Therefore, we permanently recorded the wheel-running activity (i.e., total distance, median velocity, time of breaks) of female and male mice until 9 months of age. Our records indicated higher wheel-running distances for females than males which were highest in 2-month-old mice. This was mainly reached by higher running velocities of the females and not by longer running times. However, the sex-related differences declined in parallel to the age-associated reduction in wheel-running activities. Female mice also showed more variances between the weekly running distances than males, which were recorded most often for females being 4-6 months old but not older. Additional records of 24-month-old mice of both sexes indicated highly reduced wheel-running activities at old age. Surprisingly, this reduction at old age resulted mainly from lower running velocities and not from shorter running times. Old mice also differed in their course of night activity which peaked later compared to younger mice. In summary, we demonstrated the influence of sex on the age-dependent activity profile of mice which is somewhat contrasting to humans, and this has to be considered when transferring exercise-mediated mechanism from mouse to human. (C) 2016 Published by Elsevier Inc.
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