期刊
EXPERIMENTAL GERONTOLOGY
卷 109, 期 -, 页码 47-50出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2017.02.010
关键词
LDL receptor; Reactive oxygen; Mitochondria; Atherosclerosis; Hypercholesterolemia
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2011/50400-0, 2013/07607-8]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [310546/2014-1]
- CNPq
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
Ageing and atherosclerosis are associated with oxidative stress. Mitochondrial redox function declines with ageing. Here we tested whether ageing LDL receptor knockout mice (LDLr-/-) develop spontaneous atherosclerosis and whether mitochondria' reactive oxygen species (mtROS) correlate with atherosclerosis. Compared with young mice, aged LDLr-/- mice exhibited 20-fold larger aortic lesion size, although the plasma cholesterol levels did not vary between age groups. The lesion sizes increased exponentially from 3 to 24 months of age (r = 0.92, p = 0.0001) and were correlated with mtROS across the age range (r = 0.81, p = 0.0001). Thus, LDLr-/- mice develop spontaneous diet-independent atherosclerosis, that advances exponentially with ageing. We propose that age related increases in mtROS contribute to accelerate atherosclerosis development in hypercholesterolemic mice. (C) 2017 Elsevier Inc. All rights reserved.
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