期刊
EXPERIMENTAL GERONTOLOGY
卷 96, 期 -, 页码 82-88出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2017.06.010
关键词
Glucose; Diabetes; Non-human primate; Early onset
资金
- National Natural Science Foundation of China [31472056]
- State High-Tech Development Plan of Ministry of Sciences and Technology of China [2012AA020703]
- Science & Technology Department of Guangxi Province of China [1598025-31, 20164412-3]
- Science & Technology Bureau of Nanning of China [20155192, 20163349]
Type 2 diabetes mellitus is the most common form of diabetes that occurs in both human and nonhuman primates. Although spontaneously diabetic nonhuman primates are used extensively in diabetic related research and are a proven valuable tool for the study of the natural history of diabetes, little is known about the key factors that can cause this metabolic disorder and the preventative measures that could be employed to minimize the consequences of diabetes. Using a model of developing and untreated diabetes, this study describes the effects of housing arrangement (socially group-versus individually single-housed), exercise, diet, age, and sex on fasting plasma glucose, key lipids associated with diabetes, and bodyweight in two large cohorts of nonhuman primates. Key findings include exercise/housing arrangement's contribution to significant differences in bodyweight, levels of fasting plasma glucose, total cholesterol, and high- and low-density lipoproteins. Age also had profound effects on glucose, triglyceride and high-density lipoproteins, particularly in single-caged animals. Moreover, females had higher fasting glucose, total cholesterol and triglyceride level's than male counterparts within the same housing situations. These factors may be critical to identifying preventive measures that could eventually be used to minimize obesity and diabetes in humans. (C) 2017 Elsevier Inc. All rights reserved.
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