期刊
EXPERIMENTAL EYE RESEARCH
卷 163, 期 -, 页码 78-84出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2017.06.011
关键词
Meibomian gland; Ocular surface inflammation; Contact lens; Conjunctivitis; Rosacea; Chemical burn
资金
- Wakayama Medical Award for Young Researchers
- Ministry of Education, Science, Sports and Culture of Japan [C15K10876, C24791869, C25462729]
- NEI Eye Research Grant [EY021510]
Dysfunction of the meibomian glands alters secreted meibum quantitatively and qualitatively that can lead to damage to the ocular surface epithelium. In response to an unstable tear film cause by meibomian gland dysfunction, ocular surface epithelium is damaged and expresses inflammatory cytokines leading to secondary ocular inflammation. In turn, inflammatory disorders of the palpebral conjunctiva and lid margin may affect the structure and function of meibomian gland. The disorders include allergic conjunctivitis, long-term usage of contact lenses, dermatological diseases that affect conjunctival homeostasis, Stevens Johnson's syndrome or chemical burning of the ocular surface and lid margin. (C) 2017 Published by Elsevier Ltd.
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