期刊
EMERGING INFECTIOUS DISEASES
卷 27, 期 7, 页码 1811-1820出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2707.204660
关键词
-
资金
- European Commission (Marie Sklodowska-Curie Innovative Training Network HONOURS) [721367]
- Swiss National Science Foundation (SNSF) [310030_179260, 31CA30_196062, 31CA30_196644]
- Federal Food Safety and Veterinary Office (FSVO) [1.20.02]
- German Research Foundation (DFG) [SFB 1021]
- Federal Ministry of Education and Research (BMBF) [01KI1723A]
- Swiss National Science Foundation (SNF) [310030_179260, 31CA30_196644, 31CA30_196062] Funding Source: Swiss National Science Foundation (SNF)
SARS-CoV-2 efficiently replicated in monkey and cat airway epithelial cell cultures, raising concerns about their potential role as reservoirs for the virus and highlighting the need for close surveillance.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, and the number of worldwide cases continues to rise. The zoonotic origins of SARS-CoV-2 and its intermediate and potential spiliback host reservoirs, besides humans, remain largely unknown. Because of ethical and experimental constraints and more important, to reduce and refine animal experimentation, we used our repository of well-differentiated airway epithelial cell (AEC) cultures from various domesticated and wildlife animal species to assess their susceptibility to SARS-CoV-2. We observed that SARS-CoV-2 replicated efficiently only in monkey and cat AEC culture models. Whole-genome sequencing of progeny viruses revealed no obvious signs of nucleotide transitions required for SARS-CoV-2 to productively infect monkey and cat AEC cultures. Our findings, together with previous reports of human-to-animal spillover events, warrant close surveillance to determine the potential role of cats, monkeys, and closely related species as spiliback reservoirs for SARS-CoV-2.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据