期刊
JOURNAL OF CANCER
卷 12, 期 16, 页码 4873-4882出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.58859
关键词
Long non-coding RNAs; cancer; T cell
类别
资金
- National Natural Science Foundation of China [81772779]
- Professionals from Six-Pronged Top-Talent Program of Jiangsu Province [LGY2017068]
- The Six Top Talent Project of Jiangsu Province [2015-WSN-034]
- Medical Talent of Empowering Medicine through Science and Education Program of Jiangsu Province [ZDRCA2016003]
- Key Laboratory for Medicine of Jiangsu Province of China [ZDXKB2016005]
The aberrant expressions of long non-coding RNAs (lncRNAs) in various cancers have been found to affect cancer cells, but their regulatory role in immunity, especially in T cells, also influences cancer development. However, the complex functions and regulatory mechanisms of lncRNAs in T cells need further exploration.
The discovery of many aberrant expressions of long non-coding RNAs (lncRNAs) in various cancers has focused attention on the effects of lncRNA on cancer cells themselves, including cell proliferation, growth inhibition, cell migration, cell immortality, vascular regeneration and cell viability. But with the increasing role of immunotherapy in cancer therapy, a large number of studies have revealed that the regulatory role of lncRNAs in immunity such as differentiation of immune cells can also influence the development and progression of cancer. In particular, recent publications have suggested that lncRNAs play critical roles in T-lymphocyte activation, proliferation, differentiation, function, apoptosis and metabolism. To elucidate the actual functions of lncRNAs at the molecular level of cancer pathogenesis, we summarize some of the current lncRNA regulatory mechanisms associated with T cell to discuss their effects in cancer in the hope of providing potential cancer therapeutic targets or cancer biomarkers. However, we all know that the differentiation and function of T cells is an extremely complex process that involves the expression and regulation of multiple lncRNAs. As a result, more regulatory mechanisms of lncRNAs need to be further studied.
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