期刊
EXPERIMENTAL CELL RESEARCH
卷 358, 期 1, 页码 58-64出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2017.03.024
关键词
Boundary; Eph receptor; Ephrin; Notch; Cancer; Organogenesis
资金
- National Institutes of Health [AR062110]
- Cellular and molecular basis of disease training fellowship [T32-GM08061]
- Cancer Smashers Foundation
During development, cells of seemingly homogenous character sort themselves out into distinct compartments in order to generate cell types with specialized features that support tissue morphogenesis and function. This process is often driven by receptors at the cell membrane that probe the extracellular microenvironment for specific ligands and alter downstream signaling pathways impacting transcription, cytoskeletal organization, and cell adhesion to regulate cell sorting and subsequent boundary formation. This review will focus on two of these receptor families, Eph and Notch, both of which are intrinsically non-adhesive and are activated by a unique set of ligands that are asymmetrically distributed from their receptor on neighboring cells. Understanding the requirement of asymmetric ligand-receptor signaling at the membrane under homeostatic conditions gives insight into how misregulation of these pathways contributes to boundary disruption in diseases like cancer.
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