期刊
ORGANIC CHEMISTRY FRONTIERS
卷 8, 期 19, 页码 5531-5549出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo00699a
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资金
- European Union [801378]
- ERC AdG LEAPs [692981]
- European Research Council (ERC) [692981] Funding Source: European Research Council (ERC)
Crown ethers are macrocyclic hosts that can complex a wide range of species, and their direct functionalization has been underexplored but can offer advantages in reducing synthetic effort and allowing for later modifications. Methods for direct functionalization of aliphatic and aromatic crown ethers have been sporadically reported in the literature over the past four decades, providing new ways to exploit these versatile macrocycles in contemporary supramolecular science and technology.
Crown ethers are macrocyclic hosts that can complex a wide range of inorganic and organic cations as well as neutral guest species. Their widespread utilization in several areas of fundamental and applied chemistry strongly relies on strategies for their functionalisation, in order to obtain compounds that could carry out multiple functions and could be incorporated in sophisticated systems. Although functionalised crown ethers are normally synthesised by templated macrocyclisation using appropriately substituted starting materials, the direct addition of functional groups onto a pre-formed macrocyclic framework is a valuable yet underexplored alternative. Here we review the methodologies for the direct functionalisation of aliphatic and aromatic crown ethers sporadically reported in the literature over a period of four decades. The general approach for the introduction of moieties on aliphatic crown ethers involves a radical mediated cross dehydrogenative coupling initiated either by photochemical or thermal/chemical activation, while aromatic crown ethers are commonly derivatised via electrophilic aromatic substitution. Direct functionalization routes can reduce synthetic effort, allow the later modification of crown ether-based architectures, and disclose new ways to exploit these versatile macrocycles in contemporary supramolecular science and technology.
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