期刊
EXPERIMENTAL CELL RESEARCH
卷 356, 期 1, 页码 93-103出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2017.04.016
关键词
Epidermal Growth Factor Receptor; STAT3; Apoptosis; MDA-MB-468 Cells; A431 Cells; Oncostatin M; Stattic; S3I-201
资金
- NIH [GM092874]
- Southern Regional Education Board State Doctoral Scholars Program
The Epidermal Growth Factor Receptor (EGFR) is a cell surface receptor with primary implications in cell growth in both normal and malignant tissue. Paradoxically, cell lines that hyperexpress the EGFR have been documented to undergo receptor-mediated apoptosis. The underlying mechanism by which EGF-induced apoptosis occurs however remains inexplicit. In an attempt to identify this mechanism, we assessed downstream effectors of EGFR in MDA-MB-468 cells during conditions of EGF-induced apoptosis. The effector assessment revealed STAT3 as a potential mediator of EGF-induced apoptosis. Alternative strategies for activating STAT3, independent of EGFR stimulation, resulted in the induction of the apoptotic pathways. A reduction in STAT3 expression via RNAi resulted in a significant attenuation of EGF-induced PARP cleavage. Our findings support STAT3 as a positive mediator of EGF-induced apoptosis in MDA-MB-468 cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据