A compendium of proteins that interact with HIF-1α

Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is composed of an O-2-regulated HIF-1 alpha subunit and a constitutively expressed HIF-1 beta subunit. This review provides a compendium of proteins that interact with the HIF-1 alpha subunit, many of which regulate HIF-1 activity in either an O-2-dependent or O-2-independent manner.