期刊
EXPERIMENTAL BIOLOGY AND MEDICINE
卷 242, 期 11, 页码 1136-1141出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370217708978
关键词
Circular RNA; miRNA sponge; molecular adaptor; cardiovascular disease; neuronal disease; cancer
资金
- Ministry of Science and Technology of Taiwan [MOST 104-2320-B-006-036-MY3]
- National Health Research Institute [NHRI-EX102-10244BI]
- Top University Grant of National Cheng Kung University [D10335A17]
A growing body of evidence indicates that circular RNAs are not simply a side product of splicing but a new class of noncoding RNAs in higher eukaryotes. The progression for the studies of circular RNAs is accelerated by combination of several advanced technologies such as next generation sequencing, gene silencing (small interfering RNAs) and editing (CRISPR/Cas9). More and more studies showed that dysregulated expression of circular RNAs plays critical roles during the development of several human diseases. Herein, we review the current advance of circular RNAs for their biosynthesis, molecular functions, and implications in human diseases.
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