期刊
GREEN CHEMISTRY
卷 23, 期 14, 页码 5082-5087出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1gc01210j
关键词
-
资金
- National Key R&D Program of China [2018YFB1501600]
- National Natural Science Foundation of China [21901237, 51821006, 51961135104]
- Anhui Provincial Natural Science Foundation [1908085QB53]
A visible light-mediated protocol for site-specific C(sp(3))-H hydrazination of glycine derivatives and peptides with azo compounds has been developed. This reaction proceeds smoothly under photo-irradiation conditions in the absence of any catalysts and additives, providing a convenient method for efficient preparation of unnatural alpha-amino acids and precise modification of short peptides. Mechanism investigations suggest that single electron transfer (SET) and hydrogen atom transfer (HAT) may occur during this transformation.
A visible light-mediated protocol for site-specific C(sp(3))-H hydrazination of glycine derivatives and peptides with azo compounds has been developed. This C(sp(3))-N coupling reaction proceeded smoothly under photo-irradiation conditions in the absence of any catalysts and additives, thus providing a convenient and facile method for efficient preparation of unnatural alpha-amino acids and precise modification of short peptides. Mechanism investigations revealed that single electron transfer (SET) and hydrogen atom transfer (HAT) may occur during this transformation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
