期刊
BIOMATERIALS SCIENCE
卷 9, 期 15, 页码 5209-5217出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1bm00589h
关键词
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资金
- Six Talent Peaks Project in Jiangsu Province [SWYY-243]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
The study utilizes modified NIR-II absorbing CuS NPs with mitochondria targeting TPP and CD44 targeting hyaluronic acid to achieve active photothermal ablation of tumor cells. This approach demonstrated enhanced tumor uptake and improved tumor growth suppression in in vivo experiments.
Photothermal therapy, assisted by local heat generation using photothermal nanoparticles (NPs), is an emerging strategy to treat tumors noninvasively. To improve treatment outcomes and to alleviate potential side effects on normal tissue cells, utilizing the optically transparent second near-infrared (NIR-II) window and actively targeting tumors are critical. Considering that mitochondria are heat sensitive and play an important role in the up-regulation of metabolic activity in tumor cells, herein we report a cascade targeting scheme that enables active photothermal ablation of tumor mitochondria. First, NIR-II absorbing CuS NPs were surface modified with the mitochondria targeting moiety (3-carboxypropyl) triphenylphosphonium bromide (TPP) and then shielded with CD44 targeting hyaluronic acid, which will only expose TPP upon reaching the tumor sites. This allowed over 90% CuS NP enrichment at tumor mitochondria, and as a result, significantly improved tumor cell photothermal ablation was observed at the cellular level. An in vivo study demonstrated enhanced tumor uptake and improved tumor growth suppression by using these cascade targeting CuS NPs as NIR-II photothermal agents.
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